The Telomerase Revolution

The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.

The Telomerase Revolution

Author: Michael Fossel

Publisher: BenBella Books, Inc.

ISBN: 1941631703

Page: 256

View: 340

One of Wall Street Journal’s "Best Books for Science Lovers" in 2015 Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before. In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility. Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging. Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell’s ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body’s trillions of cells. But some of our cells don’t age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young. The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade. The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.

The Telomerase Revolution

The Telomerase Revolution reveals the latest research on human aging and the enzyme telomerase which is starting to be used to slow the rate at which our cells - and we - age.

The Telomerase Revolution

Author: Michael Fossel

Publisher:

ISBN: 9781760291921

Page: 240

View: 488

We are at the beginning of a new scientific revolution. Dramatic life extension - even age reversal - has moved from science fiction to real possibility. The Telomerase Revolution reveals the latest research on human ageing and the enzyme telomerase which is starting to be used to slow the rate at which our cells - and we - age.

Key Developments in the Telomerase Revolution

This article collection reviews key developments in the medical applications of telomerase biochemistry and includes 22 open access research papers by various authors.

Key Developments in the Telomerase Revolution

Author: Applied Research Applied Research Press

Publisher:

ISBN: 9781519203557

Page: 236

View: 864

This article collection reviews key developments in the medical applications of telomerase biochemistry and includes 22 open access research papers by various authors. Topics include: Insights into the evolution of mammalian telomerase: Platypus TERT shares similarities with genes of birds and other reptiles and localizes on sex chromosomes; Mesenchymal stem cells with high telomerase expression do not actively restore their chromosome arm specific telomere length pattern after exposure to ionizing radiation; A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome; siRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells; Effect of a qigong intervention program on telomerase activity and psychological stress in abused Chinese women: a randomized, wait-list controlled trial; Glucose restriction decreases telomerase activity and enhances its inhibitor response on breast cancer cells: possible extra-telomerase role of BIBR 1532; Telomerase immunity from bench to bedside: round one; Polymorphisms within the Telomerase Reverse Transcriptase gene (TERT) in four breeds of dogs selected for difference in lifespan and cancer susceptibility; Epstein-Barr virus and telomerase: from cell immortalization to therapy; Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential; Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer; PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway; miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3zeta; Targeting DNA-PKcs and telomerase in brain tumour cells; Inhibition of telomerase activity by HDV ribozyme in cancers; Telomerase inhibition improves tumor response to radiotherapy in a murine orthotopic model of human glioblastoma; Telomere length and telomerase activity in non-small cell lung cancer prognosis: clinical usefulness of a specific telomere status; Telomerase and breast cancer; Complex roles for telomeres and telomerase in breast carcinogenesis; Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk ofcardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study; Aberrant gene expression profiles, during in vitro osteoblast differentiation, of telomerase deficient mouse bone marrow stromal stem cells (mBMSCs); The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation.

The Telomere Effect

It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

The Telomere Effect

Author: Dr. Elizabeth Blackburn

Publisher: Grand Central Publishing

ISBN: 9781455587988

Page: 416

View: 750

The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. Have you wondered why some sixty-year-olds look and feel like forty-year-olds and why some forty-year-olds look and feel like sixty-year-olds? While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free).THE TELOMERE EFFECT reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. THE TELOMERE EFFECT will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

In Vivo

3 Banks DA , Fossel M : Telomeres , cancer , and aging , altering the human
lifespan . JAMA 278 ... Vaziri H : Extension of Life Span in Normal Human Cells
by Telomerase Activation : A Revolution in Culhlral Senescence . Journal of Anti
 ...

In Vivo

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Russ Coile s Health Care Forecast

GenomOn the far side of the technology , new genetic discov ics offers the
possibility of treating the root ( genetic ) eries hold out the promise of “ anti - aging
" " The Quiet Genetics Revolution : treatments one day . Isolation of telomerase ...

Russ Coile s Health Care Forecast

Author: Russell C. Coile

Publisher:

ISBN: 9780834218727

Page: 106

View: 122

Men s Health the Hormone Revolution

Besides the telomerase enzyme and the chemical wear - and - tear caused by
free oxygen radicals , are there any other ... Recent research in the field of
endocrinology has provided us The Hormone Revolution 163 THE MALE
HORMONES ...

Men s Health   the Hormone Revolution

Author: Siegfried Meryn

Publisher: Richmond Hill, ON : NDE Pub.

ISBN:

Page: 318

View: 486

This controversial guide explores how aging affects a man's life & how hormones play a pivotal role in mental fitness, stress, mid-life crises, & virility.

New Scientist

And it was Geron that identified the gene for telomerase , the enzyme that
rebuilds the telomeres at the ends of ... prophet and wheeler" echo of the big
bang " in 1965 . things , that the universe is 13.7 billion dealer of the biotech
revolution .

New Scientist

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Visions

If we can neutralize telomerase , we can make the cells mortal again , just like
other cells . No one knows precisely which therapy will be most effective against
cancer . But the point is that the biomolecular revolution has now cracked the ...

Visions

Author: Michio Kaku

Publisher: Oxford University Press, USA

ISBN:

Page: 403

View: 223

In this text, physicist Michio Kaku looks to this future and guides the reader through the science of the next century. His vision of this future is based on the pioneering efforts by theoreticians and the current laboratory research. Dr Kaku asserts that, using today's knowledge, we can confidently predict the direction of science through the next century.

The Personalized Medicine Revolution

The Personalized Medicine Revolution explores recent advances in genomics, the study of the human genome ? as well as its cousins proteomics, metabolomics, microbiomics, and the like ? and explains how technology is even now changing the ...

The Personalized Medicine Revolution

Author: Pieter Cullis

Publisher: Greystone Books Ltd

ISBN: 1771640383

Page: 176

View: 111

Every year more than 2 million North Americans are hospitalized, and more than 100,000 lose their lives, because of adverse reactions to drugs. These tragic cases stem from our one-size-fits-all approach to medicine. But who we are-our age, our sex, our size, our ethnic heritage-matters to our health. Shouldn't our medicine be tailored to our differences? Through the stories of researchers, scientists, and patients, The Personalized Medicine Revolution explores the promising new advances in personalized medicine-healthcare based on each person's unique genetic and molecular makeup-and the coming sea change in the way we detect and treat disease. The book also discusses the issues that patients, researchers, and governments will face as we take the next steps into this exciting future and explains what readers can do to take charge of their health.

Liberation Biology

The Scientific and Moral Case for the Biotech Revolution Ronald Bailey. gives
them a big jolt of telomerase . ” 34 The dendritic cells , which now display the
telomerase protein , are injected back into a patient as a vaccine . Like all
vaccines ...

Liberation Biology

Author: Ronald Bailey

Publisher:

ISBN:

Page: 332

View: 969

An examination of the future of biology and what it will mean for humanity looks at the possibilities that recent scientific advances have made possible and discusses the ethical implications of the sciences of the future.

The Longevity Revolution

Pulitzer-prize winning author Dr. Robert Butler coined the term "ageism" and made "Alzheimer's" a familiar word.

The Longevity Revolution

Author: Robert N. Butler

Publisher: PublicAffairs

ISBN: 1586488554

Page: 576

View: 315

Dr. Robert N. Butler coined the term “ageism” and made “Alzheimer's” a familiar word. Now he brings his formidable knowledge to a recent and unprecedented achievement: the extension of human life expectancy by thirty years, and the growing number of people over age sixty-five. Alarmingly, our society has not adapted to this change. In this urgent and ultimately optimistic book, Butler calls for us to reexamine our personal and societal approach to aging right now, so that the boomers and the generations that follow may have a financially secure and vigorous final chapter of life.

Interorganellar Signaling in Age Related Disease

Developmental and tissue - specific regulation of mouse telomerase and
telomere length . Proc . Natl . Acad . ... Extension of Life Span in Normal Human
Cells by Telomerase Activation : A Revolution in Cultural Senescence . Journal of
Anti ...

Interorganellar Signaling in Age Related Disease

Author: M.P. Mattson

Publisher: Elsevier Science Limited

ISBN:

Page: 272

View: 310

Collectively, the chapters in this work will provide the reader with novel insight into the inter-relationships of the function of different organelles in the sequences of events that lead to cellular dysfunction and degeneration in the aging human population. The chapters are rich in information for cell and molecular biologists pursuing studies of the different diseases covered. In addition, the clinician will find value in understanding mechanisms underlying age-related disease as such an understanding will lead to novel therapeutic approaches for an array of age-related diseases.

Reversing Human Aging

24 A clinically effective telomerase inhibitor should be available well within ten
years and ... Scientific , medical , and public discussions will focus on the
therapeutic possibilities and the social effects of this revolution . From time to time
, we will ...

Reversing Human Aging

Author: Michael Fossel

Publisher: Quill

ISBN: 9780688153847

Page: 160

View: 628

Explains the effects of aging on the human body and describes groundbreaking medical advances in age reversal, citing their potential cures for cancer, heart disease, Alzheimer's, and stroke

Analog Science Fiction Fact

Telomeres ? " nothing but speculation about imagi“ In the middle of the twentieth
century , nary genes . ” biologists discovered that human cells Benz looked ... We
pair the telomeres in our genes . ... We are reduced version and revolution .

Analog Science Fiction   Fact

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