Furthermore, the establishment of a special pool of stem cells, the spermatogonia
, guarantees the continuity of the sperm-generation process from puberty to old
age. THE FATE OF THE MALE GERM CELL The destiny of any individual germ ...
Author: Richard Ivell
Publisher: Springer Science & Business Media
THE FASCINATION The male germ cell is the only cell of the human organism that leaves the body when it has achieved its final, highly sophisticated structure and properties. The male germ cell is designed for one purpose only: to reach the female gametes and to fertilize them. The various stages in the development of the male germ cell are characterized by proliferative phases, by the recombination of the maternal and paternal chromosomes, and by the differentiation and development of a specialized transport vehicle, the spermato zoon. Furthermore, the establishment of a special pool of stem cells, the spermatogonia, guarantees the continuity of the sperm-generation process from puberty to old age. THE FATE OF THE MALE GERM CELL The destiny of any individual germ cell is determined by a program that we know only in fragments. On the one hand every human male is able to produce many billions of germ cells in his lifetime, yet the chance of any single sperm reaching and fertilizing the female germ cell is exceedingly rare. A fertility disturbance means that somewhere during the complicated playing out of the germ cell program mistakes are made, and the program fails. It is still a fact that more than 50% of men presenting with male factor infertility have to be diagnosed as idiopathic, largely because of our lack of knowledge and conse quent lack of appropriate diagnostic tools.
The roles of mouse Y chromosome genes in spermatogenesis -- Male meiotic sex chromosome inactivation and meiotic silencing -- Insights into SRY action from sex reversal mutations -- The TSPY gene family -- Structure and function of AZFa ...
Author: Yun-Fai Lau
Publisher: World Scientific
The completion of the human genome and technological advances developed by the Human Genome Project have dramatically changed our understanding of the mechanisms underlying the development and differentiation of male germ cells, and our ability to investigate such mechanisms. This book is a timely document of advances made in the field of male gonad and germ cell research in the postgenomic era. The coverage includes the role of Y chromosome genes in male reproduction, gene expression in spermatogonial stem cells and male germ cells, and the regulation of germ cell genes in reproduction and in germ cell tumors.
Proceedings of the Third Germ Cell Tumour Conference Held in Leeds, UK on
8th-10th September 1993 W. G. Jones, P. Harnden, I. Appleyard ... Chaganti RSK
, Rodriguez E , Bos1 GJ : ( 1993 ) Cytogenetics of male germ cell tumors .
Author: W. G. Jones
Advances in the Biosciences, Volume 91: Germ Cell Tumours III documents the proceedings of the Third Germ Cell Tumor Conference held in Leeds, UK on September 8-10, 1993. This book focuses on germ cell tumors, which can be cancerous or non-cancerous tumors that normally occur inside the gonads. The topics discussed include the embryological mechanisms of maldescent and tumorigenesis; epidemiology of cryptorchidism; simultaneous bilateral testicular tumors; and mediastinal germ cell tumors. The classification of germ cell tumors; role of positron emission tomography in the assessment of germ ce ...
Studies have identified common molecular mechanisms in the specification of
germ cell lineages by determination and induction . ... oogenesis and pole cell
formation in Drosophila , germline development in C. elegans , and development
of germ cells beyond early meiosis I in male mice . ... Saitou M , Barton SC and
Surani A ( 2002 ) A molecular programme for the specification of germ cell fate in
Author: David Neil Cooper
The recent completion of important phases of the Human Genome Project heralds a new era in biomedical research, ensuring that human genetics will remain at the forefront of the public, scientific and educational consciousness. 'The Nature Encyclopedia of the Human Genome' (Nature EHG) will be the first major reference resource devoted entirely to the scientific basis and ethical, philosophical and commercial ramifications of genome research. Nature EHG will contain 1,000 articles, specially written by the world's leading experts and structured in such a way that different subsets will be useful to students, teachers, academics, researchers, and other professionals. The articles will be extensively cross-referenced and indexed and will contain many tables and illustrations. Areas to be covered include structural genomics, functional genomics, evolution and comparative genomics, genome mapping and sequencing, chromosome structure and function, population and mathematical genetics, bioinformatics, proteomics, genes and disease, behavioural and psychiatric genetics and ethical, legal and social issues.