The Fate of the Male Germ Cell

Furthermore, the establishment of a special pool of stem cells, the spermatogonia
, guarantees the continuity of the sperm-generation process from puberty to old
age. THE FATE OF THE MALE GERM CELL The destiny of any individual germ ...

The Fate of the Male Germ Cell

Author: Richard Ivell

Publisher: Springer Science & Business Media

ISBN: 1461559138

Page: 332

View: 441

THE FASCINATION The male germ cell is the only cell of the human organism that leaves the body when it has achieved its final, highly sophisticated structure and properties. The male germ cell is designed for one purpose only: to reach the female gametes and to fertilize them. The various stages in the development of the male germ cell are characterized by proliferative phases, by the recombination of the maternal and paternal chromosomes, and by the differentiation and development of a specialized transport vehicle, the spermato zoon. Furthermore, the establishment of a special pool of stem cells, the spermatogonia, guarantees the continuity of the sperm-generation process from puberty to old age. THE FATE OF THE MALE GERM CELL The destiny of any individual germ cell is determined by a program that we know only in fragments. On the one hand every human male is able to produce many billions of germ cells in his lifetime, yet the chance of any single sperm reaching and fertilizing the female germ cell is exceedingly rare. A fertility disturbance means that somewhere during the complicated playing out of the germ cell program mistakes are made, and the program fails. It is still a fact that more than 50% of men presenting with male factor infertility have to be diagnosed as idiopathic, largely because of our lack of knowledge and conse quent lack of appropriate diagnostic tools.

The Male Germ Cell

Another inference from these observations is that the female path is the " default "
path and the male path of germ - cell ... We have addressed this question by
examining the fate of germ cells with two normal X chromosomes and a Y ...

The Male Germ Cell

Author: Bernard Robaire

Publisher:

ISBN: 9780897667098

Page: 510

View: 869

Atlas of Tumor Pathology

Isochromosome genetic and molecular analysis of human male germ of the short
arm of chromosome 12 : clinically useful markcell tumors : chromosome 12
abnormalities and gene ers for male germ cell tumors . JNCI 1989 ; 81 : 1874 – 8
 ...

Atlas of Tumor Pathology

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Journal of the National Cancer Institute

the absence of association between this syndrome and development of male
germ cell tumors ( 2 ) . As Dr. Duncan points out , the cytogenetic status of the
germ cells in males with this syndrome has not been demonstrated to be
abnormal .

Journal of the National Cancer Institute

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Cumulated Index Medicus

Choi SJ , et al Acrylamide causes preimplantation abnormalities in embryos
organization of the germ cell lineage . Kloc M , et al . Anim Reprod Sci 1998 Jun
30 ; 52 ( 1 ) : 17-25 and induces chromatin - adducts in male germ cells of mice .

Cumulated Index Medicus

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Annual Review of Genetics

Transcriptional checkpoints determining the fate of male germ cells . Cell 88 : 163
-66 168. Saxena R , Brown LG , Hawkins T , Alagappan RK , Skaletsky H , et al .
1996. The DAZ gene cluster on the human Y chromosome arose from an ...

Annual Review of Genetics

Author: Allan Campbell

Publisher: Annual Reviews

ISBN:

Page:

View: 798

Science

Thus , CREM appears to directly influence the fate of male germ cells . As TLF
interacts with TFIIA , which interacts with CREM , a germ cell - specific complex
appears to operate ( Fig . 2 ) . It is noteworthy that mice lacking either CREM or
TLF ...

Science

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Prospects for Sexing Mammalian Sperm

For example , an autosomal gene for a PGK isozyme is expressed only by male
germ cells and no other cell ( Vandeberg et al . , 1973 ) . I shall illustrate the
parasitic nature of the male germ cell's existence with one striking example .

Prospects for Sexing Mammalian Sperm

Author: Rupert P. Amann

Publisher: University Press of Colorado

ISBN:

Page: 288

View: 267

The Y Chromosome and Male Germ Cell Biology in Health and Diseases

The roles of mouse Y chromosome genes in spermatogenesis -- Male meiotic sex chromosome inactivation and meiotic silencing -- Insights into SRY action from sex reversal mutations -- The TSPY gene family -- Structure and function of AZFa ...

The Y Chromosome and Male Germ Cell Biology in Health and Diseases

Author: Yun-Fai Lau

Publisher: World Scientific

ISBN: 9812770437

Page: 314

View: 415

The completion of the human genome and technological advances developed by the Human Genome Project have dramatically changed our understanding of the mechanisms underlying the development and differentiation of male germ cells, and our ability to investigate such mechanisms. This book is a timely document of advances made in the field of male gonad and germ cell research in the postgenomic era. The coverage includes the role of Y chromosome genes in male reproduction, gene expression in spermatogonial stem cells and male germ cells, and the regulation of germ cell genes in reproduction and in germ cell tumors.

Pamphlets on Biology

Finally, we must inquire into the fate of the Keimbahn-determinants in the male
germ cells. Does the Keimbahn material in these cells increase in amount, as has
been suggested for the oocytes, and is it localized in the spermatogonia, ...

Pamphlets on Biology

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Journal of Morphology

SUBJECT AND AUTHOR INDEX INCLUSIONS in male germ cells of the fowl tick
, Argas miniatus , and histogenesis of the spermatozoon . Cyto65 plasmic . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 04 日本解剖學者及動物學者諸君謹啓現下歐洲 ...

Journal of Morphology

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Germ Cell Tumours III

Proceedings of the Third Germ Cell Tumour Conference Held in Leeds, UK on
8th-10th September 1993 W. G. Jones, P. Harnden, I. Appleyard ... Chaganti RSK
, Rodriguez E , Bos1 GJ : ( 1993 ) Cytogenetics of male germ cell tumors .

Germ Cell Tumours III

Author: W. G. Jones

Publisher: Pergamon

ISBN:

Page: 456

View: 628

Advances in the Biosciences, Volume 91: Germ Cell Tumours III documents the proceedings of the Third Germ Cell Tumor Conference held in Leeds, UK on September 8-10, 1993. This book focuses on germ cell tumors, which can be cancerous or non-cancerous tumors that normally occur inside the gonads. The topics discussed include the embryological mechanisms of maldescent and tumorigenesis; epidemiology of cryptorchidism; simultaneous bilateral testicular tumors; and mediastinal germ cell tumors. The classification of germ cell tumors; role of positron emission tomography in the assessment of germ ce ...

Nature Encyclopedia of the Human Genome Genome databases Mitochondrial genome Evolution

Studies have identified common molecular mechanisms in the specification of
germ cell lineages by determination and induction . ... oogenesis and pole cell
formation in Drosophila , germline development in C. elegans , and development
of germ cells beyond early meiosis I in male mice . ... Saitou M , Barton SC and
Surani A ( 2002 ) A molecular programme for the specification of germ cell fate in
mice .

Nature Encyclopedia of the Human Genome  Genome databases   Mitochondrial genome  Evolution

Author: David Neil Cooper

Publisher:

ISBN:

Page: 1023

View: 809

The recent completion of important phases of the Human Genome Project heralds a new era in biomedical research, ensuring that human genetics will remain at the forefront of the public, scientific and educational consciousness. 'The Nature Encyclopedia of the Human Genome' (Nature EHG) will be the first major reference resource devoted entirely to the scientific basis and ethical, philosophical and commercial ramifications of genome research. Nature EHG will contain 1,000 articles, specially written by the world's leading experts and structured in such a way that different subsets will be useful to students, teachers, academics, researchers, and other professionals. The articles will be extensively cross-referenced and indexed and will contain many tables and illustrations. Areas to be covered include structural genomics, functional genomics, evolution and comparative genomics, genome mapping and sequencing, chromosome structure and function, population and mathematical genetics, bioinformatics, proteomics, genes and disease, behavioural and psychiatric genetics and ethical, legal and social issues.