Genomics of Pattern Recognition Receptors

8.2 Pattern Recognition Receptors, Gene Polymorphisms, and Atherosclerosis:
The Clinical Significance of the Chain . . . 8.3 The Association of Pattern
Recognition Receptor Polymorphisms with Myocardial Infarction and Stroke .

Genomics of Pattern Recognition Receptors

Author: Anton G. Kutikhin

Publisher: Springer Science & Business Media

ISBN: 3034806884

Page: 185

View: 173

This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.

The Human Genome Project

Innate immunity is based on the detection of common microbial molecules such
as lipopolysaccharides and peptidoglycans by a class of receptors known as
pattern recognition receptors ( 57 ) . We identified a large family of genes
encoding ...

The Human Genome Project

Author: United States. Congress. House. Committee on Science. Subcommittee on Energy and Environment

Publisher:

ISBN:

Page: 776

View: 313

Fundamentals of Microbiome Science

Its genome includes hundreds of genes with the ancient and conserved
scavenger receptor cysteine-rich (SRCR) domain. ... Pattern recognition
receptors (PRRs) identified in the genome of the sponge Amphimedon
queenslandica. A. NLRs ...

Fundamentals of Microbiome Science

Author: Angela E. Douglas

Publisher: Princeton University Press

ISBN: 0691160341

Page: 248

View: 692

An essential introduction to microbiome science, a new cutting-edge discipline that is transforming the life sciences This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. Resident microbes in healthy animals--including humans—can dictate many traits of the animal host. This animal microbiome is a second immune system conferring protection against pathogens; it can structure host metabolism in animals as diverse as reef corals and hibernating mammals; and it may influence animal behavior, from social recognition to emotional states. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet, and have contributed to animal diversification over long evolutionary timescales. Drawing on concepts and data across a broad range of disciplines and systems, Angela Douglas provides a conceptual framework for understanding these animal-microbe interactions while shedding critical light on the scientific challenges that lie ahead. Douglas explains why microbiome science demands creative and interdisciplinary thinking—the capacity to combine microbiology with animal physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science. An essential introduction to a cutting-edge field that is revolutionizing the life sciences, this book explains why microbiome science presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for many medical conditions and new strategies for pest control.

Annual Review of Genomics and Human Genetics

conducted in a candidate region (e.g., identified through linkage analysis) to
narrow the signal in a locus down to one gene from the 5–50 genes contained
within a genomic locus TRAF6. ` Innate immunity pattern-recognition receptors
and ...

Annual Review of Genomics and Human Genetics

Author:

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Genome Research

bre ise 1 ܘܢ ܐ Insights from the amphioxus genome on the origin of vertebrate.
diversified genes that contain ... IRFs : Master regulators of signalling by Toll - like
receptors and cytosolic pattern - recognition receptors . Nat . Rev. Immunol .

Genome Research

Author:

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View: 330

The Journal of Cell Biology

In addition , the fly genome encodes twelve proteins of the peptidoglycan
recognition protein family and three gram ... The macrophage scavenger receptor
is another prototypic pattern recognition receptor that plays an important role in
the ...

The Journal of Cell Biology

Author:

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No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-

Pattern Recognition Receptors Advances in Research and Application 2012 Edition

National Institutes of Health, Research Triangle Park: The Toll-Like Receptor
Gene Family Is Integrated into Human ... that the p53 tumor suppressor plays in
human biology have been greatly extended beyond “guardian of the genome. ...
variety of pathogenic threats through recognition of conserved pathogen-
associated molecular motifs,” investigators in Research Triangle Park, United
States report.

Pattern Recognition Receptors   Advances in Research and Application  2012 Edition

Author:

Publisher: ScholarlyEditions

ISBN: 1464996490

Page: 251

View: 142

Pattern Recognition Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Pattern Recognition Receptors in a concise format. The editors have built Pattern Recognition Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pattern Recognition Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Pattern Recognition Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Genetics Abstracts

Interest 3334 - G33 Gram - negative Bacterla - binding Protein , a ingly , an
underexpression of HLA - DM transcripts and protein Pattern Recognition
Receptor for Lipopolysaccharide was shown in peripheral blood B cells from RA
patients ...

Genetics Abstracts

Author:

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View: 926

Encyclopedia of Virology

Pathogenicity see also specific infections Pathogenicity determinants,
avsunviroids 5:339–341 Pathogen-specific molecular patterns (PAMPs) 5.119s ...
reassortment 3:482 PATRIC 5:357t Pattern-recognition receptors (PRRs) 3:106
apoptosis 1:161 innate immunity 3:107 interferon type I 5.119s virus-mediated
immune evasion 3:108 PAV1 virus 5:421 genome 5:422 virion composition 5:422
PAV strain ...

Encyclopedia of Virology

Author: Brian W. J. Mahy

Publisher:

ISBN:

Page:

View: 732

Covers biological, molecular, and medical topics concerning viruses in animals, plants, bacteria and insects ... this new ed. has been extensively revised and updated to reflect the 50 % increase in identified and accepted viruses since 2000. Includes information on avian flu, SARS and West Nile and the ability of some viruses to be used as agents of bioterrorism.

The Journal of Immunology

... Christina Bartholdy , Allan R. Thomsen , and Søren R. Paludan2 * Viruses are
recognized by the innate immune system through pattern recognition receptors (
PRRs ) . For instance , HSV virions and genomic DNA are recognized by TLR2 ...

The Journal of Immunology

Author:

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ISBN:

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View: 529

Annual Review of Plant Biology

The multitude of orphan MAMPs and orphan pattern recognition receptors must
be brought together . 4 . A comparison of genomes may help in finding candidate
genes of unknown PRRs for orphan MAMPs . 5 . It might be promising to ...

Annual Review of Plant Biology

Author:

Publisher:

ISBN:

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View: 228

Immunology for Life Scientists

... T cell antigen receptor diversity “ Similarity to self rule ” – limited diversity
Diverse TCR repertoire Genomic organisation ... review 3.2 Phagocytosis 3.2.1
Pattern recognition receptors Complement receptor 3 ( CR3 ) CD14 Toll - like
receptors ...

Immunology for Life Scientists

Author: Lesley-Jane Eales

Publisher: Wiley-Interscience

ISBN:

Page: 337

View: 947

This thoroughly revised and updated new edition provides outstanding coverage of the most important aspects of immunology. Assuming no previous knowledge of the subject, the book gives step-by-step detail on topics such as antigens, hypersensitivity, autoimmunity, reproductive immunity and immunodeficiency. There is an accompanying website with supplementary material.

Intersection of Lipid Metabolism and the Innate Immune Response to Mycobacterial Infection

Sequencing of the M . leprae genome showed massive gene decay as compared
with M . tuberculosis , entire metabolic pathways are ... Recognition of
mycobacteria by innate immune receptors The innate immune system is able to
distinguish self from non - self by recognizing conserved pathogen - associated
molecular patterns ( PAMPs ) utilizing pattern - recognition receptors ( PRRs )
that signal to ...

Intersection of Lipid Metabolism and the Innate Immune Response to Mycobacterial Infection

Author: Dennis Jay Montoya

Publisher:

ISBN:

Page: 226

View: 907

Polish Journal of Microbiology

The new strategy of identification of the potential protective antigens based on in
silico analysis of bacterial genomes , termed “ reverse vaccinology ” ... TLR
receptors belong to a large family of PRR receptors ( pattern recognition
receptors ) .

Polish Journal of Microbiology

Author:

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View: 894

Program and Proceedings

UPREGULATION OF PATTERN RECOGNITION RECEPTORS ON A
MACROPHAGE RAW264.7 CELL LINE IN ... Pattern recognition receptors (
PRRs ) are expressed by innate cells , such as macrophages , and alert the
immune response to invading pathogens . ... of aerial hyphae will be tested
further by sequencing the colony's genome and comparing it to Mycobacterium
smegmatis wild type .

Program and Proceedings

Author: Nebraska Academy of Sciences. Annual Meeting

Publisher:

ISBN:

Page:

View: 434