Circulating Nucleic Acids in Plasma and Serum

This volume encompasses the proceedings of the 6th international conference on circulating nucleic acids in plasma and serum held from the 9th to the 11th of November 2009 in Hong Kong.

Circulating Nucleic Acids in Plasma and Serum

Author: Peter B. Gahan

Publisher: Springer Science & Business Media

ISBN: 9789048193820

Page: 285

View: 177

DNA and RNA fractions have been isolated from the whole blood, serum, plasma, the surface of blood cells, urine, saliva and spinal fluid from both healthy individuals and clinical patients. Recent developments are presented concerning the isolation, quantification and analysis of these molecules and their use in the identification of specific nucleic acid fragments related to a variety of clinical disorders thereby permitting their early diagnosis and prognosis.

Circulating Nucleic Acids in Serum and Plasma CNAPS IX

The book will present the progress made since the last meeting in fall 2013 concerning the analysis of circulating extra-cellular nucleic acids.

Circulating Nucleic Acids in Serum and Plasma     CNAPS IX

Author: Peter B. Gahan

Publisher: Springer

ISBN: 9783319824871

Page: 220

View: 202

The book will present the progress made since the last meeting in fall 2013 concerning the analysis of circulating extra-cellular nucleic acids. There are a modest number of laboratories involved in this field, nevertheless the number of papers published by researchers is extensive. The articles which will be published in this meeting report will be a valuable contribution for researchers and research students alike and will help them to stay on top of the developments in different research areas and to „cross borders“ between them.

Circulating Nucleic Acids in Plasma and Serum V

This volume reports on the most recent progress in this field, including chapters on developing protocols for nucleic acid extraction, determining the origin of the circulating nucleic acids, the capacity of these nucleic acids to enter ...

Circulating Nucleic Acids in Plasma and Serum V

Author: Peter B. Gahan

Publisher: Blackwell Pub

ISBN:

Page: 345

View: 765

DNA and RNA fractions have been isolated from whole blood, serum, plasma, the surface of blood cells, and urine from both healthy persons and patients. Specific fragments have been identified as being related to particular disorders, for example, diabetes, cancer, myocardial infarction, and stroke. The ability to isolate these fractions and assess their relationship to specific diseases makes early noninvasive diagnosis possible. This volume reports on the most recent progress in this field, including chapters on developing protocols for nucleic acid extraction, determining the origin of the circulating nucleic acids, the capacity of these nucleic acids to enter cells and exhibit biological activity, isolating and testing fetal cells from maternal blood, and discussing the clinical implications of these discoveries and developing the techniques that will bring them into clinical application. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Annals of the New York Academy of Sciences Circulating Nucleic Acids in Plasma and Serum V

This volume reports on the most recent progress in this field, including chapters on developing protocols for nucleic acid extraction, determining the origin of the circulating nucleic acids, the capacity of these nucleic acids to enter ...

Annals of the New York Academy of Sciences  Circulating Nucleic Acids in Plasma and Serum V

Author: Peter Gahan

Publisher: Wiley-Blackwell

ISBN: 9781573317344

Page: 352

View: 475

DNA and RNA fractions have been isolated from whole blood, serum, plasma, the surface of blood cells, and urine from both healthy persons and patients. Specific fragments have been identified as being related to particular disorders, for example, diabetes, cancer, myocardial infarction, and stroke. The ability to isolate these fractions and assess their relationship to specific diseases makes early noninvasive diagnosis possible. This volume reports on the most recent progress in this field, including chapters on developing protocols for nucleic acid extraction, determining the origin of the circulating nucleic acids, the capacity of these nucleic acids to enter cells and exhibit biological activity, isolating and testing fetal cells from maternal blood, and discussing the clinical implications of these discoveries and developing the techniques that will bring them into clinical application. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Circulating Nucleic Acids in Plasma serum III and Serum Proteomics

Serum proteomics is introduced as a new topic to CNAPS and is expected to provide yet another platform for breakthrough discoveries. Serum proteomics topics will address both cancer and early pregnancy.

Circulating Nucleic Acids in Plasma serum III and Serum Proteomics

Author: Dave S. B. Hoon

Publisher:

ISBN:

Page: 325

View: 150

Numerous questions remain regarding the origin, release, clearance, clinical utility, and possible functionality of circulating nucleic acids. Serum proteomics is introduced as a new topic to CNAPS and is expected to provide yet another platform for breakthrough discoveries. Serum proteomics topics will address both cancer and early pregnancy.

Circulating Nucleic Acids in Plasma Or Serum II

This volume reviews and summarizes research regarding the origin, release, clearance and possible functionality of circulating nucleic acids, and points toward future developments in the field.

Circulating Nucleic Acids in Plasma Or Serum II

Author: Y. M. Dennis Lo

Publisher:

ISBN: 9781573313780

Page: 295

View: 723

The biology and diagnostic applications of circulating nucleic acids have gained research momentum in the last few years before the publication of this study. In particular, tumour-derived DNA in the plasma or serum of cancer patients has shown promise for the diagnosis and monitoring of many types of cancer, and the discovery of foetal DNA in maternal plasma or serum opens up new possibilities for non-invasive prenatal genetic analysis. This volume reviews and summarizes research regarding the origin, release, clearance and possible functionality of circulating nucleic acids, and points toward future developments in the field.

Circulating Nucleic Acids in Plasma and Serum IV

The focus in this volume is on three major applications of the circulating nucleic acids detection method: cancer, fetal medicine, and diseases such as diabetes, stroke, and myocardial infarction.

Circulating Nucleic Acids in Plasma and Serum IV

Author: R. Swaminathan

Publisher: Wiley-Blackwell

ISBN: 9781573316279

Page: 372

View: 431

An accurate, inexpensive, and noninvasive method for the early diagnosis of cancer has been something of a holy grail among cancer researchers, but until recently a method meeting all three criteria has been elusive. Nucleic acids were first discovered in circulation in 1948, but it was not until the 1960s and 70s that patients with autoimmune disease and cancer were discovered to have higher levels of circulating DNA than were detected in in healthy persons. The focus in this volume is on three major applications of the circulating nucleic acids detection method: cancer, fetal medicine, and diseases such as diabetes, stroke, and myocardial infarction. In addition, there are reports on the biology and origins of circulating DNA and RNA and on improved methods for the detection of nucleic acids in plasma and serum. The circulating DNA found in cancer patients has many characteristics in common with their tumors, which made it an attractive candidate for use in the diagnosis and management of patients with malignancies. This method can also be applied to the assessment of the sublinical tumor burden in cancer patients, thus reducing the risk of unnecessary chemotherapy. Detection of nucleic acids circulating in maternal serum means that fetal diagnosis may be possible without resorting to the more dangerous and invasive methods now used (e.g., amniotic fluid and chorionic villus sampling). Detection of problems in the pregnancy such as preeclampsia and intrauterine growth retardation may also become possible through maternal blood samples. In diabetic patients, circulating nucleic acids can be used for the early detection of developments such as retinopathy. The benefits of using circulating nucleic acids in the diagnosis and management of cancer and chronic disease will be realized through earlier detection by means of this less expensive and less invasive testing technique and through its potential for closer monitoring of the disease. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Circulating Nucleic Acids in Plasma Or Serum

This volume, taken from the proceedings of a conference in August 1999, discusses such issues.

Circulating Nucleic Acids in Plasma Or Serum

Author: Philippe Anker

Publisher:

ISBN: 9781573312691

Page: 188

View: 652

Free DNA present in both healthy and diseased human plasma has been found to express specific point mutations that may serve as diagnostic signposts - perhaps to reliable, non-invasive tests for breast and lung cancer, haematopoetic malignancies, colorectal or pancreatic carcinoma, and other tumours. In another research area, foetal DNA has been detected in maternal serum which presents an early-horizon alternative in utero test for gender. A parallel discovery of rearranged immunoglobin heavy-chain DNA in the plasma of patients wit Hodgkin's disease or acute B cell leukaemia has also emerged. These fast-emerging indicators suggest that it is time to standardize research techniques and develop protocols that can take a measure of circulating DNA's usefulness as a diagnostic tool. This volume, taken from the proceedings of a conference in August 1999, discusses such issues.

Circulating Nucleic Acids in Early Diagnosis Prognosis and Treatment Monitoring

The areas covered in this volume include: · Background and general biology of circulating nucleic acids · Methodology · Applications of circulating nucleic acids · Quality Assurance · Ethics

Circulating Nucleic Acids in Early Diagnosis  Prognosis and Treatment Monitoring

Author: Peter B. Gahan

Publisher: Springer

ISBN: 9401791686

Page: 471

View: 512

DNA and RNA fractions can be isolated from a variety of body fluids including whole blood, serum, plasma, urine, saliva and cerebrospinal fluid from both patients and healthy individuals. Such isolates can be exploited in the early detection of clinical disorders, stratification of patients for treatment, treatment monitoring and clinical follow-up. In addition, the use in fetal medicine allows the early detection of fetal sex, Rh factor and aneuploid disorders as well as following both fetal and premature born infant development. This volume is intended as a primer for those who are interested in entering the field of circulating nucleic acids. The areas covered in this volume include: · Background and general biology of circulating nucleic acids · Methodology · Applications of circulating nucleic acids · Quality Assurance · Ethics

Anticancer Research

To the best of our knowledge , this was also the first study to investigate the
relationship between the plasma expression of circulating hТERT DNA and the
serum level of CA 15.3 in BC patients before surgery , and to analyze their
association ...

Anticancer Research

Author:

Publisher:

ISBN:

Page:

View: 347

Journal of the National Cancer Institute

use of different procedures to quantify circulating DNA ) on the variability of
quantitative assays . ... REFERENCES NOTES ( 1 ) Anker P , Mulcahy H , Stroun
M. Circulating nucleic acids in plasma and serum as a noninvasive investigation
for ...

Journal of the National Cancer Institute

Author:

Publisher:

ISBN:

Page:

View: 902

"Summaries of papers" contained in the journal accompany each issue, 19--

Annals of Clinical Biochemistry

Apoptosis is believed to play an important role in the generation of circulating
DNA in healthy subjects as well as in cancer patients . Jahr et al.41 and Giacona
et al.42 have shown that most DNA molecules present in plasma / serum have ...

Annals of Clinical Biochemistry

Author:

Publisher:

ISBN:

Page:

View: 682

Genome Research

Mechanisms of DNA demethylation in chicken embryos . ... 5 - Methylcytosine
DNA glycosylase participates in the genome - wide loss of DNA methylation
occurring during mouse myoblast ... Circulating nucleic acids in plasma / serum .

Genome Research

Author:

Publisher:

ISBN:

Page:

View: 226

Annals of the New York Academy of Sciences Circulating Nucleic Acids in Plasma and Serum V

This volume reports on the most recent progress in this field, including chapters on developing protocols for nucleic acid extraction, determining the origin of the circulating nucleic acids, the capacity of these nucleic acids to enter ...

Annals of the New York Academy of Sciences  Circulating Nucleic Acids in Plasma and Serum V

Author: Peter Gahan

Publisher: Wiley-Blackwell

ISBN: 9781573317344

Page: 352

View: 901

DNA and RNA fractions have been isolated from whole blood, serum, plasma, the surface of blood cells, and urine from both healthy persons and patients. Specific fragments have been identified as being related to particular disorders, for example, diabetes, cancer, myocardial infarction, and stroke. The ability to isolate these fractions and assess their relationship to specific diseases makes early noninvasive diagnosis possible. This volume reports on the most recent progress in this field, including chapters on developing protocols for nucleic acid extraction, determining the origin of the circulating nucleic acids, the capacity of these nucleic acids to enter cells and exhibit biological activity, isolating and testing fetal cells from maternal blood, and discussing the clinical implications of these discoveries and developing the techniques that will bring them into clinical application. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Cancer Research

Circulating Res 2006 ; 66 : 11293-7 . cell - free DNA : a novel biomarker for
response to 10. Liu HS , Jan MS , Chou ... Prak ET , Kazazian HH , Jr. Mobile
elements and the circulating tumor cells and of tumor DNA in plasma human
genome . Nat Rev Genet 2000 ; 1 ... Utility of circulating B - RAF DNA mutation in
serum for monitoring melanoma patients receiving biochemotherapy . Clin
Cancer Res 2007 ...

Cancer Research

Author:

Publisher:

ISBN:

Page:

View: 167