Apoptosis in Carcinogenesis and Chemotherapy

Therefore, this book will be not only for laboratory-based molecular and cell biologists and biochemists in cancer research but also for clinical oncologists and those working in the pharmaceutical and biotechnological industries.

Apoptosis in Carcinogenesis and Chemotherapy

Author: George G. Chen

Publisher: Springer Science & Business Media

ISBN: 140209597X

Page: 384

View: 499

Although research on carcinogenesis has focused more on cellular proliferation than on cell death, yet understanding the mechanism of apoptosis may have important implications for cancer therapy. This book brings together experts from around the world who will discuss the common cancers encountered in clinical practice in the laboratory setting. During the induction of these common cancers, the role of apoptosis in cellular and molecular changes is emphasized, critically highlighting possible anti-cancer strategies. For those who are interested in carcinogenesis and for those who are seeking new approaches to anti-cancer therapy, this book is an important reference. It serves not only as a reference of the current understanding of apoptosis in common cancers but also an important bridge between the laboratory and clinical practice. The editors and contributors are to be congratulated in bringing together an important pool of up-to-date knowledge to light and further our interest in this exciting and expanding ?eld. Arthur K. C. Li Emeritus Professor of Surgery The Chinese University of Hong Kong v Preface The role of apoptosis in cancer development and emerging treatment strategies has rapidly expanded over the past few years. The novel discovery in the apoptotic pa- ways and their relevant molecules provides us not only the knowledge how tumors develop but also the opportunity to design new therapeutic tools to prevent or inhibit the growth of tumors with minimal side-effects. Undoubtedly, understanding the events involved at a molecular level can permit the manipulation of apoptosis for therapeutic purposes.

Journal of the National Cancer Institute

Overexpression of BCL2 generally suppresses mitochondria less , the approach
of celecoxib - based combination regimens for mediated apoptosis induced by
many chemicals or small mole cancer chemoprevention and therapy and ...

Journal of the National Cancer Institute

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Anticancer Research

Oxidative stress is involved in a variety of different cellular processes including
apoptosis ( 23 ) , and sulforaphane ... Moriarty RM , Hawthorne M , Mehta RG ,
Moon RC and Pezzuto JM : Cancer chemopreventive potential of sulforamate , a
 ...

Anticancer Research

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Role of Capsaicin in Oxidative Stress and Cancer

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of ...

Role of Capsaicin in Oxidative Stress and Cancer

Author: Sanjay K. Srivastava

Publisher: Springer Science & Business Media

ISBN: 9400763174

Page: 178

View: 142

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

The Royal Marsden Hospital Handbook of Cancer Chemotherapy

Chapter 2 Combination chemotherapy and chemotherapy principles Michelle
Scurr , ... The ultimate effectors of apoptosis are a family of enzymes termed
caspases ( cysteine proteases that are activated specifically in apoptotic cells
and ...

The Royal Marsden Hospital Handbook of Cancer Chemotherapy

Author: David Brighton

Publisher: Churchill Livingstone

ISBN:

Page: 563

View: 847

Covering key areas in the administration of chemotherapy for cancer sufferers, this text also includes a CD-ROM with footage of important aspects such as cannulation and giving intravenous drugs.

Apoptosis and Cancer Therapy

Becker , C. et al . , TGF - beta suppresses mediated induction of mdr1b
expression tumor progression in colon cancer by ... Sci USA paB sensitizes non -
small cell lung cancer 1998 , 95 : 2307-12 . cells to chemotherapy - induced
apoptosis .

Apoptosis and Cancer Therapy

Author: Klaus-Michael Debatin

Publisher: Wiley-Blackwell

ISBN:

Page: 1159

View: 587

Since most cancer therapies primarily act by inducing apoptosis in tumor cells, insights into the molecular mechanisms regulating apoptosis are crucial to developing novel, more effective treatment strategies. Here, a highly distinguished team of authors from top institutes around the world leads readers from the principles of programmed cell death to the role of apoptosis in cancer development and emerging treatment strategies. Divided into two distinct parts, the first focuses on apoptosis signaling, covering in depth such topics as mitochondria, effector systems, the Bcl-2 family, IAPs, survival pathways, tumor suppressor genes, modulators, lysosomes and phagocytosis. The second section goes on to analyze apoptosis in cancer and cancer therapy, with a detailed look at model systems, molecular diagnosis, cellular stress, DNA damage and repair, molecular targets and therapeutic aspects. With its strong focus on recent developments in cancer therapy, this book is aimed at oncologists, molecular and cell biologists, biochemists, and those working in the pharmaceutical and biotechnological industries.

Cancer Genetics and Therapeutics

The book discusses cancer and the potential use of phytochemicals as cancer therapeutics.

Cancer Genetics and Therapeutics

Author: Madhumita Roy

Publisher: Springer Nature

ISBN: 9811394717

Page: 227

View: 835

The book discusses cancer and the potential use of phytochemicals as cancer therapeutics. It begins with the basics of cancer, including the definition, types, etiology and molecular mechanisms involved, before discussing the fundamentals of diagnosis, treatment and associated problems as well as remedial measures. Since cancer is not a single disease, and the mechanisms of carcinogenesis are different for different cancers, it examines the genes and proteins involved in carcinogenesis, and signal transduction pathways for each individual cancer type. Further, the book reviews the latest research on phytochemicals for cancer treatment, highlighting their anti-cancer properties, sources, structure, active biomolecules and probable mechanisms of action, and describing their biochemical properties in the context of cancer prevention and treatment.

Therapeutic Oligonucleotides

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in
response to apoptotic stimuli . ... Proliferation , cell cycle and apoptosis in cancer .
Nature 411 ... Apoptosis : a link between cancer genetics and chemotherapy .

Therapeutic Oligonucleotides

Author: Yoon S. Cho-Chung

Publisher:

ISBN:

Page: 266

View: 765

Explores the potential for the development of therapeutic oligonucleotides into clinical medicines and their use as basic research tools, which is the proceedings of the 7th NIH Symposium on Therapeutic Oligonucleotides. This book focuses on antisense, RNAi, triple-helix, gene repair, DNA chips, and CpG immune modulatory oligonucleotides.

Comprehensive Management of Head and Neck Tumors

pauses to consider that something is probably wrong with apoptotic mechanisms
in cancer cells . Cancer cells are ... Thus , the assumption that chemotherapy can
trigger normal apoptosis in cancer cells may be overly optimistic . " 14 The ...

Comprehensive Management of Head and Neck Tumors

Author: Stanley E. Thawley

Publisher: W B Saunders Company

ISBN: 9780721655987

Page: 1981

View: 478

Cancer Research

Isothiocyanates as cytochrome c and apoptosis in human prostate cancer cancer
chemopreventive agents : their biological activi cells . Cancer Res 2006 ; 66 :
5828-35 . ties and metabolism in rodents and humans . Curr Drug 19. Kim H ,
Kim ...

Cancer Research

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Experimental Biology and Medicine

Induction of apoptosis by cancer chemotherapy . Exp Cell Res 256 : 42 - 49 ,
2000 . 23 . Ameyar M , Atfi A , Zhenzi C , Stancou R , Shatrov V , Bettaieb A .
Chouaib S . Analysis of human breast adenocarcinoma MCF - 7 resistance to
tumor ...

Experimental Biology and Medicine

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International Journal of Oncology

( P.M. Comoglio - Italy ) Chemoprevention of esophageal and lung cancer by
isothiocyanates . ( G.D. Stoner - USA ) T ... ( T. Boulikas - USA ) • Signaling by
Ras - related proteins in the regulation of cell growth and apoptosis . ( J.C. Lacal -
Spain ) ...

International Journal of Oncology

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The Scientific Bases of Cancer Chemoprevention

Proceedings of the International Forum on the Scientific Bases of Cancer
Chemoprevention, 31 March-2 April 1996, Bologna, ... The phenomenon of
apoptosis was first defined in the 1970s and has since been recognized to be
widespread in ...

The Scientific Bases of Cancer Chemoprevention

Author: Cesare Maltoni

Publisher: Elsevier Science Health Science Division

ISBN:

Page: 290

View: 823

Hardbound. This volume brings together experts in the fields of molecular biology and carcinogenesis, epidemiologists, pathologists, experimental and clinical oncologists, to review the basic biological knowledge on chemoprevention; and the available results and ongoing studies in the practical application of potential chemopreventive agents for cancer control. On the basis of the available data, the forum further evaluates the potential of these new tools, and indicates future directions for research in this area.

Mechanisms of Resveratrol induced Apoptosis in Cancer

actions , RES has been demonstrated to interfere with apoptosis pathways both
by directly triggering apoptosis - promoting signaling ... In addition , RES targets
several important enzymes involved in carcinogenesis ; the mitochondrial
electron transport chain proteins ... to the synthesis of derivatives that are more
efficacious growth inhibitory and apoptotic agents in chemoprevention and
chemotherapy .

Mechanisms of Resveratrol induced Apoptosis in Cancer

Author: Dhruv Sareen

Publisher:

ISBN:

Page: 130

View: 462

Journal of the National Cancer Institute

Overexpression of BCL2 generally suppresses mitochondria less , the approach
of celecoxib - based combination regimens for mediated apoptosis induced by
many chemicals or small mole cancer chemoprevention and therapy and ...

Journal of the National Cancer Institute

Author:

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"Summaries of papers" contained in the journal accompany each issue, 19--

Ovarian Cancer

If the mechanism underlying the protective effects of OCPs involves the apoptotic
effects of progestins , and not ovulation inhibition , it may be possible : ( 1 ) to
develop a chemopreventive strategy using progestins ; and ( 2 ) to apply this ...

Ovarian Cancer

Author: Ian J. Jacobs

Publisher: Oxford University Press, USA

ISBN:

Page: 427

View: 639

Ovarian cancer provides an up-to-date and comprehensive synthesis of clinical management and research progress in the field of epithelial ovarian cancer. The book has its origins in two separate but complementary initiatives. One initiative was a series of reviews commissioned to cover thespectrum of clinical management of ovarian cancer from prevention, screening and diagnosis to surgery, chemotherapy and palliative care. The reviews were invited from an international panel of clinicians with expertise in the management of ovarian cancer. The second initiative was co-ordinated bythe Helene Harris Memorial Trust (HHMT) which has organised key biennial meetings on ovarian cancer for the last 12 years. Attendance at the meetings is by invitation to a small group of international authorities on research aspects of ovarian cancer. Setting the clinically focused reviewsalongside the HHMT research focused chapters has created a unique book. First, the book is unusually up-to-date and presents recent advances not included in other books in this field. Second, the contents are comprehensive and cover aetiology, pathology, screening, prevention, diagnosis,prognostic techniques, surgery, adjuvant therapy and palliative care. Third, the review chapters are set alongside more detailed coverage of recent clinical and basis science developments. Examples of this are the coverage of familial cancer, prevention, screening, and current therapy which areconsequently much more topical and exciting. Fourth, there are sections on 'tumour biology' and 'novel therapies' which have not been covered in comparable books about ovarian cancer. Finally, the contributions are from a representative spectrum of experts from both research and clinicalbackgrounds and with a truly international perspective.

In Vivo

... amebiasis , ultrasound , drainage , neurological symptoms , 1027 BRCA1 ,
gene therapy , ovarian cancer , apoptosis ... lung cancer , 635 Breast cancer ,
radiotherapy , chemotherapy , pulmonary function tests , 867 Breast cancer ,
sentinel ...

In Vivo

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