Androgens. in. Castration-Recurrent. Prostate. Cancer. James L. Mohler and
Mark A. Titus Abstract AR remains active in ... Androgen Action in Prostate
Cancer, 553 DOI: 10.1007/978-0-387-69179-4_23, # Springer Science +
Business Media, ...
Author: Donald Tindall
Publisher: Springer Science & Business Media
Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor. Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included
In this situation , the benefit that derives from androgen could relate to the ability
of this steroid to enhance production or potentiate the action of the ESF . That
relative refractoriness to the ESF may actually exist in some situations is ...
Author: Thomas Lincoln Casey
Records of meetings 1808-1916 in v. 11-27.
The volume opens with a brief review of the research history on androgen action and prostate carcinogenesis, followed by chapters that cover state-of-the-art methods to determine androgen levels in biological tissues and fluids, ...
Author: Fahri Saatcioglu
Publisher: Humana Press
Androgens play a critical role in the development and maintenance of the male reproductive system and affect important physiological processes and pathological conditions, including the homeostasis of the normal prostate and prostate cancer. Androgen Action: Methods and Protocols is designed to provide a tool box to study various phases of androgen action, from its entry to the cell to the phenotypic response that the cell mounts, with up-to-date techniques for biochemists, molecular biologists, cell biologists, geneticists, and pathologists. The volume opens with a brief review of the research history on androgen action and prostate carcinogenesis, followed by chapters that cover state-of-the-art methods to determine androgen levels in biological tissues and fluids, experimental procedures to study the various aspects of androgen receptor activity, and methodology to study salient examples of interactions between androgen signalling and other major signalling pathways in cells. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Androgen Action: Methods and Protocols provides a comprehensive overview of, and practical guidance on, the diverse methodologies that are propelling androgen action research forward, both for normal physiology as well as in disease states.
Finally, the androgen receptor is presented as a viable target for novel therapies. Together, these reviews should give the reader a comprehensive conceptual framework of androgen action in prostate cancer.
Author: Patrice Enjalbert
Publisher: Springer Verlag
"This volume contains the proceedings of the tenth annual Symposium on Theoretical Aspects of Computer Science (STACS '93), held in W}rzburg, February 25-27, 1993. The STACS symposia are held alternately in Germany and France, and organized jointly by the Special Interest Group for Theoretical Computer Science of the Gesellschaft f}r Informatik (GI) and theSpecial Interest Group for Applied Mathematics of the Association Francaise des Sciences et Technologies de l'Information et des Syst mes (afcet). The volume includes the three invited talks which opened the three days of the symposium: "Causal and distributed semantics for concurrent processes" (I. Castellani), "Parallel architectures: design and efficient use" (B. Monien et al.), and "Transparent proofs" (L. Babai). The selection of contributed papers is organized into parts on: computational complexity, logic in computer science, efficient algorithms, parallel and distributed computation, language theory, computational geometry, automata theory, semantics and logic of programming languages, automata theory and logic, circuit complexity, omega-automata, non-classical complexity, learning theory and cryptography, and systems."--PUBLISHER'S WEBSITE.
By developmental restriction of steroid-metabolising enzymes, the activity of
certain androgen receptor systems can be ... First, even among the male
accessory sexual glands, models of androgen action based exclusively on the
formation and ...
Author: W.I.P. Mainwaring
Publisher: Springer Science & Business Media
My introduction to androgens was neither auspicious nor impressive. I was sitting my viva voce examination for a degree in physiology and had haltingly intimated to my examiner (name decorously withheld) that I intended to pursue a career in re search. "On what topic?" was the reply. I had been deeply impressed by the work of C. Huggins and C. V. Hodges (Cancer Res. 1, 293, 1941) on the dramatic arrest of canine prostatic hyperplasia by the administration of stilboestrol. With some en thusiasm, I responded, "On steroid hormones, because I am struck by the profound effects that may be achieved by relatively small numbers of molecules. " The examiner sank into deep contemplation before replying, "Young man, have you considered go ing into teaching?" Suitably chastened, I finally began my research career investigating the effects of steroids on the nucleic acid metabolism of experimental tumours and on the process cells. Reaching an impasse in this work, I mentioned one of senescence in animal day to Dr. G. F. Marrian that, somewhat surprisingly, we had no understanding of the fundamental mechanism of action of steroid hormones, especially the androgens. me to tackle this problem, particularly since exciting new insights He encouraged were then being made into the interaction of radioactively labelled oestradiol-l?,8 with such tissues as rat uterus.
Biochemical Features of Androgen Action ) H. G. Williams - Ashman James
Buchanan Brady Urological Institute , The Johns Hopkins Hospital , and
Department of Pharmacology and Experimental Therapeutics , The Johns
Hopkins University ...
Author: Schering Symposium on Biodynamics and Mechanism of Action of Steroid Hormones
Advances in Biosciences 2 documents the proceedings of the Schering Symposium on Biodynamics and Mechanism of Action of Steroid Hormones held in Berlin, on 14-16 March 1968. The volume begins by presenting the opening address on the symposium's main themes followed by a lecture on the factors influencing the nature and significance of research in the biological sciences. The papers presented cover topics such as methods for automatic and semi-automatic assay of steroids; the combination of gas chromatography and mass spectrometry for the investigation of complex mixtures; factors controlling s ...
Androgen Action at the Cellular Level Marty E . Sawaya Department of Medicine ,
Division of Dermatology and Cutaneous Surgery , University ... Historically , the
effects of androgens have been classed as either androgenic or anabolic ( 1 ) .
Author: Geoffrey P. Redmond
Publisher: Raven Press (ID)
Describes interpretation of androgen levels in women/ovarian pathology in androgenic disorders/acne vulgaris/etc.
Androgens are required for the structural and functional integrity of the prostate.
Author: Feng Jiang
Androgens are required for the structural and functional integrity of the prostate. Androgen action is intimately involved in the pathogenesis of two major prostate diseases, benign prostatic hyperplasia (BPH) and prostate carcinoma (CaP). Androgens regulate gene expression in the prostate through the androgen receptor (AR), a ligand-dependent transcription factor. To understand the molecular and cellular mechanisms of androgen action in the prostate, I used both cDNA subtractive hybridizations and microarray to comprehensively identify genes regulated by androgens using the rat ventral prostate model. Twenty-two genes up-regulated by androgens were isolated from my subtraction studies. From my microarray study, 162 and 143 genes were found to be up-regulated and down-regulated by androgens, respectively. Identification of these genes suggests that the following pathways are activated by androgens in the prostate---metabolism, protein synthesis, protein chaperoning and trafficking, secretions, cell cycle and apoptosis, and structural and extracellular proteins. I have characterized four androgen-responsive genes: FPPS, PLZF, GADD45gamma, and U19. FPPS is abundantly expressed and regulated by androgens in the rat prostatic epithelial cells. Both PLZF and GADD45gamma are found to be growth-suppressive to prostate cancer cells, suggesting that androgens might activate a signaling pathway to counteract the androgen-induced cell proliferation pathway. U19, a novel androgen-responsive apoptosis inducer, is also growth-suppressive to prostate cancer. Therefore, U19 was chosen for further mechanistic study. I identified FBI as a protein partner for U19. I determined that FB1 also interacts with EAF1, PML and ELL, and FB1 inhibits the transcriptional activity of U19. In conclusion, my thesis established a foundation for future mechanistic study of androgen action and provided new insights into the roles played by androgens in the prostate.